- Sales & Marketing Consultant, Holton
- Salvage Yards, Junk Yards & Wrecker Service, Holton
- Sandwich Shop Restaurants, Holton
- Satellite TV Service, Holton
- Screen Printing, Holton
- Secondary Schools, Holton
- Security Brokers & Dealers, Holton
- Seed Companies, Holton
- Seeds & Bulbs Wholesale & Growers, Holton
- Septic Tank Installation & Repair, Holton - Septic Systems
- Septic Tank Pumping & Cleaning, Holton - Septic Systems
- Septic Tanks & Septic Systems Contractors, Holton - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewing & Yarn Stores & Supplies, Holton
- Sewing Machine Repair & Service, Holton
- Sharpening Service, Holton
- Sheet Metal, Holton
- Shopping & Shopping Services, Holton
- Signs, Holton
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- Ski Centers, Holton
- Ski Resorts, Holton
- Small Engine Parts Wholesale, Holton
- Social Services & Welfare, Holton
- Societies & Foundation Associations, Holton
- Solar Equipment, Holton
- Specialty Animal Services, Holton
- Specialty Stores, Holton
- Spill Control Equipment & Service, Holton
- Staffing & Support Services, Holton
- State Government, Holton
- Steak House Restaurants, Holton
- Stocks & Bond Brokers, Holton
- Stone & Rock Quarry, Holton - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Submarine Sandwich Restaurants, Holton
- Suicide Prevention Service & Counseling, Holton
- Surveyor Services, Holton - Surveying Service
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