- Obstetricians & Gynecologists, Louisburg - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Office Supplies, Equipment & Office Furniture Stores, Louisburg
- Oil Change & Lubrication, Louisburg - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Louisburg - Oil Companies
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Louisburg
- Opticians, Louisburg
- Optometrists, Louisburg - Eye Doctors, Physicians & Surgeons (Optometry)
- Ornamental Greenhouses, Louisburg
- Ornamental Nursery, Louisburg
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