- Sand Gravel & Aggregate, Clay Center
- Sandwich Shop Restaurants, Clay Center
- Satellite TV Service, Clay Center
- Scrap & Waste Materials, Clay Center
- Screen Printing, Clay Center
- Secondary Schools, Clay Center
- Secretarial School, Clay Center
- Security Brokers & Dealers, Clay Center
- Senior Citizens Service & Health Organizations, Clay Center
- Shirts & T-Shirts, Clay Center
- Shoe Stores, Clay Center - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Clay Center
- Siding Contractors, Clay Center - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Social Clubs & Organizations, Clay Center
- Social Services & Welfare, Clay Center
- Societies & Foundation Associations, Clay Center
- Special Education & Care, Clay Center
- Special Events & Party Supply Rental, Clay Center
- Specialty Stores, Clay Center
- Sporting Goods Stores, Clay Center
- State Government, Clay Center
- Steel & Metal Goods, Clay Center - Steel Distributors
- Stocks & Bond Brokers, Clay Center
- Stone & Rock Quarry, Clay Center - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Substance Abuse Clinics, Clay Center - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Clay Center - Surveying Service
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